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BP: Fachverband Biologische Physik

BP 18: Focus session: Integrative Structural Modeling

Wednesday, March 11, 2026, 10:30–12:45, BAR/0106

Modern biological questions - and the growing recognition that biomolecular dynamics are central to molecular function - demand increasingly integrated technological strategies to probe the structure and behavior of biomolecules. Yet bringing insights from diverse experimental techniques together in a rigorous, quantitative way remains a formidable challenge, requiring deep expertise across methods as well as sophisticated modeling approaches. This focus session aims to ignite collaboration at this interface. By gathering experimentalists with complementary skill sets and researchers specializing in computational and theoretical modeling, we will create a space for vibrant exchange, cross-disciplinary learning, to lead to the development of well-informed, predictive models of complex biological systems.

Organized by Richard Börner (HS Mittweida) and Sigrid Milles (FMP Berlin)

	10:30	BP 18.1	Invited Talk: Protein complex structure prediction, state-of-the-art and challenges — •Ezgi Karaca
	11:00	BP 18.2	Extending the Fluorophore Dye Library for FRET-guided Modeling — •Isolde Kirk, Felix Erichson, Josephine Meitzner, Patrick K. Quoika, and Richard Börner
	11:15	BP 18.3	Structural dynamics and long-range interactions controlling timing of the Neurospora circadian clock — •Muriel Hartsch, Ida Marie Vedel, Kathrin Motzny, Michael Brunner, and Sigrid Milles
	11:30		15 min. break
	11:45	BP 18.4	Invited Talk: From Sparse Restraints to All-Atom Models: Integrative Reconstruction of Hidden GPCR Conformations — •Matthias Elgeti
	12:15	BP 18.5	RNA 3D Folding Using Diffusion Models and Agentic Tree Search — •Arunodhayan Sampathkumar and Danny Kowerko
	12:30	BP 18.6	RNA adsorption in confinement, from electrostatic properties to spatial organization — •Horacio V. Guzman, Willy Menacho, and Ian Addison-Smith