Dresden 2026 – scientific programme
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BP: Fachverband Biologische Physik
BP 26: Biomaterials and Biopolymers (joint session BP/CPP)
BP 26.11: Talk
Thursday, March 12, 2026, 12:30–12:45, BAR/SCHÖ
Multiplex sensing of respiratory viruses using surface plasmon resonance spectroscopy — •Ghazaleh Eshaghi1, David Kaiser1, Hamid Reza Rasouli1, Dominik Gary2, Tobias Fischer2, Katrin Frankenfeld2, Abhishek Sharma3, and Andrey Turchanin1 — 1Institute of Physical Chemistry, Friedrich Schiller University Jena, 07743 Jena — 2Forschungszentrum für Medizintechnik und Biotechnologie (fzmb) GmbH, 99947 Bad Langensalza, Germany — 3BioNavis Ltd., Hermiankatu 6-8H, 33720 Tampere, Finland
We present label-free and real-time biosensing of three major respiratory viruses using the Multi-Parametric Surface Plasmon Resonance (MP-SPR) technique. In this approach, MP-SPR SPR Au sensors are functionalized with ultrathin (~1 nm) azide-terminated carbon nanomembranes (N3-CNMs), enabling covalent attachment of virus-specific antibodies and thereby providing selective immobilization of target antigens on the sensor surface. We demonstrate specific detection of SARS-CoV-2, Influenza A, and Respiratory Syncytial Virus (RSV) antigens with negligible cross-reactivity and high reproducibility in both PBS-P buffer (physiological pH) and clinically relevant nasopharyngeal swab matrices. For SARS-CoV-2, Influenza A, and RSV antigens, we determine dissociation constants (KD) of 7.0 * 0.5 nM, 86 * 4 pM, and 3.0 * 0.2 pM, respectively, with corresponding limits of detection (LOD) of ~65 pM, ~80 pM, and ~2 pM.
Keywords: Multiplexed biosensing; respiratory viruses; surface plasmon resonance; carbon nanomembrane; Label-free detection