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BP: Fachverband Biologische Physik

BP 26: Biomaterials and Biopolymers (joint session BP/CPP)

BP 26.9: Vortrag

Donnerstag, 12. März 2026, 12:00–12:15, BAR/SCHÖ

Stimulus-induced biomechanical perturbations via smart hydrogel microstructures — •Katja Zieske — Max Planck Institute for the Science of Light, Erlangen, Germany

Cells reside within complex three-dimensional extracellular matrices, where mechanical interactions play essential roles in tissue development, and disease progression. To mimic these interactions, we developed a lab-on-a-chip platform that applies spatially and temporally controlled mechanical perturbations using intelligent hydrogel microstructures.

First, we optimized material composition and photopolymerization parameters and demonstrated reliable, stimulus-dependent expansion and contraction of the hydrogel microstructures within microfluidic chambers. Using these microstructures, we then applied compressive forces to Matrigel and collagen networks. Finally, we applied mechanical perturbations to cellular systems.

By mimicking cellular pushing forces with hydrogel microstructures, this lab-on-a-chip system provides a versatile tool for studying mechanical remodeling of biopolymers and cellular systems.

Keywords: smart hydrogel; microfabrication; extracellular matrix; biomechanics; collagen