Dresden 2026 – scientific programme
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BP: Fachverband Biologische Physik
BP 33: Bioimaging
BP 33.7: Talk
Thursday, March 12, 2026, 17:00–17:15, BAR/0205
Photothermal chemical imaging of nano-structured cells and cell organelles with less than 5 nm resolution — Maryam Ali1,2, Christin David1,3, and •Daniela Täuber1,2 — 1Friedrich Schiller University Jena — 2Leibniz Institute of Photonic Technology, Jena — 3University of Applied Sciences Landshut, Germany
Mid-infrared photoinduced force microscopy (PiF-IR) is a new imaging technique that enables the chemical characterization of surfaces with an unprecedented spatial and high spectral resolution. PiF-IR bridges the gap between high-resolution structure elucidation using electron microscopy, fluorescence microscopy and conventional infrared spectroscopy. It is complementary to tip-enhanced Raman spectroscopy (TERS). PiF-IR was successfully applied to map the local chemistry and structure of the antibiotic interaction on the surface of individual bacterial cells with a resolution of a few nanometers using the model system Bacillus subtilis and vancomycin [Ali et al., Anal. Chem., 2025, 97, 23914] and to map the surface of retina pigment organelles. Frequently observed anisotropic signal distributions on soft nanostructures in tip-enhanced photothermal imaging methods could be attributed to hybrid field coupling in a study combining modeling and experiment [Anindo et al., J. Phys. Chem. C, 2025, 129, 4517].
Keywords: photothermal imaging; nanostructures; cell surface; infrared spectroscopy; hybrid field coupling