Dresden 2026 – scientific programme

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BP: Fachverband Biologische Physik

BP 7: Poster Session I

BP 7.42: Poster

Monday, March 9, 2026, 15:00–17:00, P5

Dynamics of confined immune cell migration — •Santiago Kuhl and Joachim Rädler — Ludwig-Maximilians-Universität, München, Germany

Immune cells must invade tissue to reach their targets, but the dynamics and mechanics of their invasiveness are not well understood at the single cell level. Photolithographically fabricated 3D hydrogel micro-structures provide a promising platform for probing cellular invasiveness. Here we use nonadhesive 3D dumbbell-microcavities to enforce repeated encounters between single cells and pores of varying dimensions, simulating migration in a dense extracellular matrix. This platform enables us to record trajectories of macrophages and dendritic cells and measure dwell times and transmigration probabilities as a function of confinement.

Keywords: cell migration; invasiveness; immune cells; micropatterns