Dresden 2026 – scientific programme
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BP: Fachverband Biologische Physik
BP 7: Poster Session I
BP 7.48: Poster
Monday, March 9, 2026, 15:00–17:00, P5
BeadBuddy: Multiscale shape analysis of in-vivo stress sensors for force inference — •Alejandro Jurado Jiménez1, Jonas Isensee3, Arne Hofemeier2, Lea Johanna Krüger4, Raphael Wittkowski5, Ramin Golestanian3, Philip Bittihn3, and Timo Betz1 — 1Third Institute of Physics-Biophysics, University of Göttingen — 2Institute of Pharmacology and Toxicology, University Medical Center Göttingen — 3Max-Planck-Institute for Dynamics and Self-Organization, Göttingen — 4Institute of Theoretical Physics, University of Münster — 5Department of Physics, RWTH Aachen University, DWI - Leibniz Institute for Interactive Materials
The measurement of stresses and forces at the tissue level has proven to be an indispensable tool for the understanding of complex biological phenomena such as cancer invasion, embryo development, or wound healing. One of the most versatile tools for force inference at the cell and tissue level are elastic force sensors, whose biocompatibility and tunable material properties make them suitable for many different experimental scenarios. The evaluation of those forces, however, is still a bottleneck due to the numerical methods seen in the literature until now, which are usually slow and render low experimental yield. Here, we present BeadBuddy, a ready-to-use platform for the evaluation of deformation and stresses from fluorescently labeled sensors within seconds. The strengths of BeadBuddy lie in the precomputed analytical solutions of the elastic problem, the abstraction of data into spherical harmonics, and a simple user interface that creates a smooth workflow for force inference.
Keywords: Force inference; Mechanosensing; Biophysics tools; Elastic sensors; Toolbox