Dresden 2026 – scientific programme
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BP: Fachverband Biologische Physik
BP 7: Poster Session I
BP 7.50: Poster
Monday, March 9, 2026, 15:00–17:00, P5
Connecting tissue stiffness and glycosylation patterns in the developing brain — •Sarah Fritsche1,2, Sebastián Vásquez-Sepúlveda1,2, Leonhard Möckl3,4, and Kristian Franze1,2,5 — 1Medical Institute of Biophysics, FAU Erlangen-Nuremberg, Germany — 2MPZPM, Erlangen, Germany — 3Department of Medicine 1/CITABLE, University Hospital Erlangen, FAU Erlangen-Nuremberg, Germany — 4MPL, Erlangen, Germany — 5Department of Physiology, Development and Neuroscience, University of Cambridge, United Kingdom
Mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy (MOGHE) is a pathological entity leading to drug resistant epilepsy that is characterised by increased density of oligodendroglial cells, hypomyelination, and heterotopic neurons in the white matter. This malformation has been linked to mutations of the galactose transporter SLC35A2. At the same time, processes like brain folding involve motion and must therefore be driven by large scale forces. This is why, in order to comprehend this disease to a greater extent, we are investigating the connection between the physical properties of brain tissue and its glycosylation patterns to emulate brain malformations in the Xenopus laevis embryo. The physical properties are measured via atomic force microscopy and the glycosylation patterns via super-resolution microscopy of metabolically labelled galactose, as well as antibody- and lectin stainings. With this approach we aim to understand the relation between the mechanical properties of brain tissue and developmental pathologies.
Keywords: glycosylation; atomic force microscopy; super-resolution microscopy; extracellular matrix; translational research