Dresden 2026 – scientific programme

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BP: Fachverband Biologische Physik

BP 9: Single Molecule Biophysics

BP 9.3: Talk

Monday, March 9, 2026, 17:30–17:45, BAR/0205

Single-molecule force and torque spectroscopy reveals conformational transitions in DNA and proteins — •Jan Lipfert — Universität Augsburg

Magnetic tweezers are a powerful tool to probe single molecules under precisely controlled forces, down to well below 1 pN, and, in addition can control twist and torque. Here, I highlight recent developments and applications of magnetic tweezers. In particular, I will present how we use magnetic tweezers to probe regulatory conformational changes in protein complexes, including pathogen-cell adhesion and the initiation of primary hemostasis by von Willebrand factor. In addition, I will show how we use the capabilities of magnetic tweezers to precisely measure DNA helicity under changes in environmental conditions and upon small-molecule binding.

Keywords: magnetic tweezers; protein conformational changes; DNA conformations; force; torque