Dresden 2026 – scientific programme
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 26: French-German Session: 2D Materials, Thin Films and Interfaces II
CPP 26.5: Talk
Tuesday, March 10, 2026, 15:15–15:30, HÜL/S386
Irreversible protein adsorption on mobile surfaces: control and modelling of surface density and in-plane mobility through molecular crowding — Wanchung Chiang1, Lionel Bureau1, Ralf Richter2, Galina Dubacheva1, and •Delphine Debarre1 — 1Grenoble-Alpes University, France — 2University of Leeds, UK
Adsorption of proteins onto surfaces has been the focus of a wealth of experimental, theoretical and numerical studies but surprisingly little is known on the dynamics of protein adsorption on fluid surfaces.
In this study, we consider irreversible adsorption of streptavidin, a protein with a very strong affinity for its ligand biotin, onto a lipid bilayer incorporating biotin-terminated lipids, a widely-used model to build biomimetic surfaces. We show that after the initial, rapid adsorption phase, a slower, logarithmic continuous adsorption can lead to surface densities much larger than in the absence of surface diffusion. Simultaneously, we quantify the lateral diffusion of the adsorbed proteins, which drops sharply and can be tuned continuously over two orders of magnitude depending on surface density.
We then adapt free-volume theories to two dimensions to rationalize our findings and bridge the gap between in-plane diffusion and adsorption dynamics. Beyond a better understanding of adsorption onto mobile surfaces, our data paves the way towards biomimetic surfaces incorporating mobility control of functional groups.
Keywords: protein adsorption; surface functionalization; surface mobility