Regensburg 2002 – wissenschaftliches Programm
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SYBM: Physik biologischer Materie
SYBM 202: Spectroscopy of single biomolecules
SYBM 202.4: Vortrag
Dienstag, 12. März 2002, 15:45–16:00, H37
Self Assembly of Biomaterials in Microfluidic Devices — •Thomas Pfohl and Alexander Otten — Angewandte Physik, Universität Ulm, Albert-Einstein-Allee 11, D-89069 Ulm
Using microfluidic channel devices, we are able to process biomaterials, such as DNA and F-actin, under static and dynamic conditions.1 Structural arrangements of these filamentous molecules and self assembled materials are probed by using polarization, fluorescence and confocal Raman-microscopy. The influence of the geometric constraints on the biomaterials can be analyzed by studying the fluctuations of single filaments in dilute solutions and by investigating the linear alignment of filament bundles along the microchannels in higher concentrated solutions. The time evolution of the self assembly of biomaterials can be studied with a microfluidic diffusive mixing device2, consisting of crossed microchannels. Our first experiments are focused on the bundling of DNA induced by small inorganic and organic ions.
1 T. Pfohl et al., Langmuir 17, 5343 (2001)
2 J. B. Knight et al., Phys. Rev. Lett. 80, 3863 (1998)