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SYBM: Physik biologischer Materie

SYBM 302: Biomolecular mechanics

SYBM 302.1: Talk

Tuesday, March 12, 2002, 17:00–17:15, H37

Processive Behavior of Molecular Motors Under Tangential Loading — •Parmeggiani Andrea 1, Frank Jülicher2, Luca Peliti3, and Jacques Prost21Theoretische Physik, Hahn-Meitner-Institut Berlin, Germany — 2Physico-Chimie Curie, Institut Curie, Paris, France — 3Dipartimento di Scienze Fisiche and Unità INFM, Università "Federico II", Napoli, Italy

We propose a general framework to study the processivity of a molecular motor moving along a polar filament and submitted to a tangential load. Among several interesting results, our study of specific models suggests that the average attachment time of a motor decreases with increasing ATP concentration and that double-headed motors such as kinesins lose their processivity under forcing conditions while processive single-headed motors are less sensitive to tangential forcing.

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