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SYND: Nonequilibrium Dynamics of Biomolecules

SYND 1: Sitzung 1

SYND 1.2: Invited Talk

Thursday, March 25, 2004, 14:30–15:00, HS 332

Investigating Ultrafast Peptide Dynamics by 2D-IR Spectroscopy — •Peter Hamm, Jens Bredenbeck, and Jan Helbing — Universität Zürich, Physikalisch Chemeisches Institut, Winterthurerstr. 190, 8075 Zürich, Schweiz

Recent work has shown that two-dimensional infrared (2D-IR) spectroscopy might be a valuable experimental complement to existing tools to study conformation of small peptides in the solution phase. 2D-IR spectroscopy allows one to measure the couplings between certain vibrational modes, which are related to the relative orientation of the peptide units, and hence allows one to extract structural information. Great progress has been achieved recently in resolving the structure, structural distribution and structural fluctuations of a small peptide, trialanine. The most promising potential of 2D-IR spectroscopy is its intrinsic high time resolution (1 ps), which freezes in all motions of a peptide backbone. On the one hand, this allows one to resolve rapidly exchanging conformations of an equilibrium ensemble of peptides. On the other hand, one can monitor how a non-equilibrium ensemble evolves in time with 1 ps time resolution. The emerging possibilities of 2D-IR spectroscopy will be discussed.