Regensburg 2004 – wissenschaftliches Programm

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AKB: Biologische Physik

AKB 23: Membranes

AKB 23.3: Hauptvortrag

Dienstag, 9. März 2004, 17:30–18:00, H40

Protein Micropatterns in Supported Lipid Membranes — •Motomu Tanaka — Biophysics Lab, Tech. Univ. Munich

The design of soft, compatible interfaces between solids and biological materials is an interdisciplinary challenge for scientific and biotechnological applications. Planar cell surface models can be designed by deposition of lipid membranes on ultrathin polymer supports that play the role of extracellular matrix and glycocalix. As physical models of cell surfaces, several methods have been developed to fabricate micropatterns of proteins in supported membranes, such as (i) accumulation of membrane-associated proteins by electrophoresis and (ii) confinement of proteins in membrane micropatterns. The first method utilizes fluid supported membranes as a quasi-2D matrix to separate membrane proteins under lateral electrical fields, while the second includes the micropatterning of biocompatible polymer supports. Such strategies are promising for complimentary coupling of bioorganic functional systems and semiconductor devices by matching of the lateral dimensions of biofunctional micro-patterns and device arrays.