Regensburg 2004 – wissenschaftliches Programm
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AKB: Biologische Physik
AKB 50: Poster Session "Biological Physics"
AKB 50.57: Poster
Freitag, 12. März 2004, 10:30–13:00, B
Production and Mechanical Properties of Designed Porous Ceramic Scaffolds — •Alexander Woesz1,2, Monika Rumpler3, Juergen Stampfl4, Franz Varga3, Nadja Fratzl-Zelman3, Paul Roschger3, Klaus Klaushofer3, and Peter Fratzl1,2 — 1Max Planck Institute of Colloids and Interfaces, Dept. of Biomaterials, Germany — 2Erich Schmid Institute of Materials Science, Austrian Academy of Sciences, Austria — 3Ludwig Boltzmann Institute of Osteology, 4th med. Dept., Hanusch Hospital and UKH Meidling, Austria — 4Institute of Materials Science and Testing, Vienna University of Technology, Austria
Scaffolds made of porous calcium phosphates are potentially interesting as bone replacement materials. We use a rapid prototyping method based on microstereolithography and ceramic gelcasting to fabricate highly porous hydroxylapatite scaffolds suited as substrate for bone cells, whose strength and stiffness can be adjusted within a certain range. Generally mechanical properties of cellular solids depend on the apparent density, the architecture and the properties of the dense material. We showed in compression tests of cellular structures produced by selective laser sintering that the strength and stiffness as well as the defect tolerance can be varied independently from each other by a factor of three, just by changing the architecture. The scaffolds have been investigated in cell culture experiments, they were found to support the growth of mouse osteoblasts. The osteoblasts covered the whole external and internal surface of the scaffold, they were embedded in an extra cellular matrix consisting of collagen.