Regensburg 2004 – wissenschaftliches Programm
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AKB: Biologische Physik
AKB 50: Poster Session "Biological Physics"
AKB 50.86: Poster
Freitag, 12. März 2004, 10:30–13:00, B
Growth of the Mineral Particles in Bone - Combined Study of Small Angle X-ray Scattering (SAXS) and Electron Backscattering (qBEI) — •A. Valenta1,2, P. Roschger2, B.M. Misof2, O. Paris3, W. Tesch1,2, S. Bernstorff4, H. Amenitsch5, K. Klaushofer2, and P. Fratzl3 — 1Erich Schmid Inst. of Material Science, Austrian Academy of Sciences and Inst. of Metal Physics, University of Leoben, Leoben, Austria — 2L. Boltzmann Inst. of Osteology, 4th Med. Dept., Hanusch Hospital & UKH-Meidling, Vienna, Austria — 3Max Planck Inst. of Colloids and Interfaces, Dept. of Biomaterials, Potsdam, Germany — 4Sincrotrone Trieste S.C.p.A., Basovizza, Trieste, Italy — 5IBR, Austrian Academy of Sciences, Graz, Austria
Bone is a nanofiber composite formed by mineralized collagen fibrils. In this study bone areas from human biopsies with different degree of mineralization were investigated. The mineral volume fraction (φ) was assessed by qBEI, and then the particle surface per volume (σ) was determined by scanning-SAXS using a micro focus (20 micron) synchrotron x-ray beam. A biphasic correlation between φ and σ was found: In the φ-range of 0-27 vol% mineral σ showed a monotone increase, whereas in the range of 27-40 vol% σ remained constant. This finding suggests, that after nucleation, mineralization proceeds by a rapid predominant- 2-dimensional growth of the mineral particles, followed by a slow increase in thickness.