Berlin 2005 – wissenschaftliches Programm

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AKB: Biologische Physik

AKB 100: Poster Session I

AKB 100.78: Poster

Samstag, 5. März 2005, 16:45–18:45, Poster TU D

Dynamics of DNA looping under tension — •Ulrich Gerland — Department Physik and CENS, LMU München, Germany

The interaction of proteins bound to DNA is often dependent on the formation of DNA loops. The dynamics of this process can be probed in detail by applying a force to the ends of the DNA with single-molecule techniques. Motivated by ongoing experiments, I study both the equilibrium statistics and the dynamics of DNA looping under tension, using a combination of numerical and analytical techniques. In particular, I characterize the force-dependence of the peak in the looping probability and looping rate as a function of the separation between the DNA sites. I will discuss how the looping kinetics under tension can be used to indirectly obtain information on enzymes whose action depends on DNA looping.