Berlin 2005 – wissenschaftliches Programm
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AKB: Biologische Physik
AKB 200: Poster Session II
AKB 200.16: Poster
Dienstag, 8. März 2005, 17:00–19:00, Poster TU C
Model of intracellular Ca2+ oscillations due to negative feedback — •Peter Borowski1, Jürgen Reidl2, Anke Sensse3, Martin Zapotocky1, Jens Starke2, and Markus Eiswirth3 — 1Max Planck Institute for Physics of Complex Systems, Dresden — 2Institute of Applied Mathematics, University of Heidelberg & WIN-Research Group of Olfactory Dynamics, Heidelberg Academy of Science and Humanities — 3Fritz-Haber-Institute of the Max Planck Society, Berlin
We present a mathematical model for calcium oscillations and fast adaptation in the cilia of olfactory sensory neurons. Stoichiometric network analysis is used for analysing the kinetic equations and finding the oscillatory regime. The underlying mechanism is based on direct negative feedback and does not require any autocatalysis such as calcium-induced calcium release. Results of the model using physiological parameter values agree quantitatively with experiment, both with respect to oscillations and to fast adaptation. The bifurcation diagram of the model is calculated to make predictions regarding the occurence of oscillations.