Berlin 2005 – wissenschaftliches Programm

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AKB: Biologische Physik

AKB 200: Poster Session II

AKB 200.26: Poster

Dienstag, 8. März 2005, 17:00–19:00, Poster TU C

Neuronal signal transmission in reconstructed neuronal networks on microfluidic Si-based devices: Towards an artificial chemical synapse chip — •Yulia Mourzina¹, Petra Schulte¹, Dmitri Kaliaguine², Simone Böcker-Meffert¹, and Andreas Offenhäusser¹ — ¹Institute of Thin Films and Interfaces, Research Center Jülich, Germany — ²Faculty of Chemistry, St. Petersburg State University, Russia

Chemical synaptic transmission, the elementary interaction event between neuronal cells, is fundamental to understanding learning and memory. In order to perform long term studies about neuronal interactions in reconstructed neuronal networks, we intend to form an ‘artificial chemical synapse‘ with spatially and temporally resolved non-invasive chemical stimulation and detection methods.

We reconstruct the defined synaptical connections of cortical neuronal cells on microfluidic Si-based chips and align the reconstructed neuronal networks with microapertures connecting the microfluidic compartments. Natural conditions of chemical synapses are simulated by means of providing localized chemical stimuli to the cells with neurotransmitters via microfluidics. Cell response is characterized by means of electrophysiological recordings. Further on, we intend to develop a non-invasive recording of the synaptic events in neuronal networks by means of electrochemical methods.