Berlin 2005 – wissenschaftliches Programm
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AKB: Biologische Physik
AKB 200: Poster Session II
AKB 200.33: Poster
Dienstag, 8. März 2005, 17:00–19:00, Poster TU C
Organophosphonate monolayers as functionalisation for silicon based biosensing devices — •Karin Buchholz1, Michael D. Carolus2, Jeffrey Schwartz2, Marc Tornow1 und Gerhard Abstreiter1 — 1Walter Schottky Institut, TU München, 85748 Garching, Germany — 2Department of Chemistry, Princeton University, Princeton, New Jersey 08544-1009
Planar semiconductor sensing devices based on silicon-on-insulator (SOI) substrates have immense potential for applications such as label-free, fast, and time resolved detection of biomolecule binding events due to their great sensitivity to surface potential changes via the field effect [1].
Phosphonate films are easy to apply and provide for stable silicon surface derivatization because they give dense, self-assembled monolayers that bond strongly to the native silicon oxide and that can be modified with tailored, substituted end groups [2].
We investigated the stability and current blocking properties of different alkylphosphonate layers over time by cyclic voltammetry and impedance spectroscopy. A maximum current blocking of 97 per cent at the reductive peak voltage of a reference sample was observed for samples coated with layers of hydroxyundecylphosphonic acids.
Concepts for biofunctionalisation of SOI sensors via Phosphonate acid monolayers will be discussed.
[1] M. G. Nikolaides et al., ChemPhysChem, vol. 4, 1104-1106 (2003)
[2] K. S. Midwood et al., Langmuir, vol. 20, 5501-5505 (2004)