Berlin 2005 – wissenschaftliches Programm
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CPP: Chemische Physik und Polymerphysik
CPP 30: POSTER: Chemical physics
CPP 30.17: Poster
Dienstag, 8. März 2005, 16:30–18:30, Poster TU D
Organically doped sol-gel materials for applications in photodynamic therapy and optical sensing — •Halina Podbielska1,2, Agnieszka Ulatowska-Jarza1,3, Uwe Bindig3, HansJ. Eichler2,3, and Gerhard Müller4 — 1Bio-Optics Group, Institute of Physics, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, PL-50370 Wroclaw, Poland — 2Institute of Optics, Technical University Berlin, Strasse des 17 Juni 135, D-10623 Berlin, Germany — 3Laser-und Medizin-Technologie Berlin, Fabeckstr. 60-62, D-14195 Berlin, Germany — 4Charite Universitätsmedizin Berlin, Campus Benjamin Franklin, Institut für Medizinische Physik und Lasermedizin, Fabeckstr. 60-62, D-14195 Berlin, Germany
The optical properties of photosensitive dyes as may be used for photodynamic therapy or for sensing, entrapped in silica sol-gels, are examined. Our idea is to construct a fiberoptic light applicator which can act as a carrier for photosensitizers. Two photoagents were examined: protoporphyrine PP IX and chlorophyll based Photolon, immobilized in sol-gel coatings on optical fibers. Absorption and emmission spectra were measured in air and varous environments. It was shown that the dyes preserve their chemical activity, do not leave sol-gel pores, and may contact with even large molecules from external environment. Additionaly, we observed that photosensitizers entrapped in sol-gel coatings are sesnitive to hydrogen ions, so thus they can be used for pH sensing.