Berlin 2005 – wissenschaftliches Programm

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ST: Strahlen- und Medizinphysik

ST 5: Medizinphysik: Strahlentherapie mit Ionen II

ST 5.5: Fachvortrag

Dienstag, 8. März 2005, 14:00–14:15, TU HL1

Synchrotron Stereotactic Radiotherapy for the treatment of brain tumors: dosimetric aspects for clinical trials — •Caroline Boudou¹, Marie-Claude Biston¹, Aurélie Joubert¹, Jean-François Adam¹, Anne-Marie Charvet¹, Claudio Ferrero², François Estève^1,3, and Hélène Elleaume¹ — ¹INSERM-U647 "Rayonnement synchrotron et recherche médicale", Grenoble, France — ²European Synchrotron Radiation Facility ESRF, Grenoble, France — ³Unité IRM, Centre Hospitalier Universitaire, Grenoble, France

In synchrotron stereotactic radiotherapy (SSR) the tumor is loaded with atoms of high atomic number (Z), prior to a sliced irradiation performed with a fitted monochromatic low energy x-ray beam from a synchrotron source. This method is under investigation at the European Synchrotron Radiation Facility (ESRF) for the treatment of brain tumors. Very encouraging results obtained on a rat’s model disclose new perspectives for clinical trials.

Commercial treatment planning systems are not suitable for this new technique since the beam energy, the irradiation geometry and the potential presence of high Z elements differ from conventional systems. We designed an interface for dose computation based on a Monte Carlo code (MCNPX); and studied the use of various radiosensitive gels for experimental dosimetry using the synchrotron radiation. The communication will describe these dosimetry methods.