Dresden 2006 – wissenschaftliches Programm

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DY: Dynamik und Statistische Physik

DY 46: Poster

DY 46.24: Poster

Donnerstag, 30. März 2006, 16:00–18:00, P1

Spindle Oscillations in Thalamocortical Oscillators: From a conductance-based biophysical model to an extended Hindmarsh-Rose model — •Jörg Mayer, Jens Christian Claussen, and Heinz Georg Schuster — Institut für Theoretische Physik und Astrophysik, Christian-Albrechts Universität, Olshausenstraße 40, 24098 Kiel, Germany

In the last ten years electrophysiological measurements in thalamic slices helped to gain more insight into the thalamocortical system. In particular sleep spindles have been investigated thoroughly by extracellular and intracellular patch-clamp recordings in thalamic cells. Based on these data the thalamocortical system is a structure for which computational models can be extremely useful in in order to understand the relationship between underlying dynamics and biophysics.
We use an extended Hinsmarsh-Rose model to reproduce a recent experiment by Le Masson et al. on the thalamocortical loop. In this framework we analyze the underlying dynamical mechanisms which lead to spindle oscillations. We find that ionic currents which work on different timescales lead to spindle oscillations and influence the information transfer in thalamocortical loops significantly. [1]

[1] Jörg Mayer, Heinz Georg Schuster, and Jens Christian Claussen, The role of inhibitory feedback for information processing in thalamocortical circuits, arxiv.org e-print q-bio/0510040