Regensburg 2007 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 16: Poster Session I
BP 16.39: Poster
Dienstag, 27. März 2007, 17:00–19:30, Poster D
Detection of Coupling Directions in Multivariate Dynamical Systems with Applications to Tremor-Correlated Spike Activity in Parkinson's Disease — •Bjoern Schelter1, Kathrin Henschel1, Florian Amtage2, Jan Vesper3, Bernhard Hellwig2, Carl Hermann Luecking2, and Jens Timmer1 — 1FDM, Center for Data Analysis and Modeling, University of Freiburg, Germany — 2Dpt. of Neurology and Neurophysiology, Neurozentrum, University of Freiburg, Germany — 3Dpt. of Stereotactic Neurosurgery, Neurozentrum, University of Freiburg, Germany
Tremor in Parkinson's disease is a neurological disorder that manifests itself in involuntary oscillations of the upper limbs at a frequency of approximately 5 Hz. The aim of this study was to investigate the relation between tremor and spike activity in the subthalamic nucleus (STN) of patients with Parkinson's disease.
Data were obtained during stereotactic surgery on patients with Parkinson tremor. Muscular and neuronal spike activity was recorded simultaneously. Multivariate analysis techniques were applied to infer the underlying interdependence structure with particular emphasize on distinguishing direct and indirect interdependencies as well as the direction of the information flow. The techniques were successfully applied and our results support the hypothesis that synchronous neuronal activity in the STN contributes to the pathogenesis of Parkinsonian tremor.