Regensburg 2007 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 2: Protein Function
BP 2.2: Vortrag
Montag, 26. März 2007, 12:30–12:45, H43
Myoglobin solvated in glycerol-water mixtures: The interplay of solvent and protein dynamics. — •Florian Kargl1, Helen Jansson1, Felix Fernandez-Alonso2, and Jan Swenson1 — 1Department of Applied Physics, Chalmers University of Technology, SE-41296 Göteborg, Schweden — 2Rutherford Appleton Laboratory, Chilton, Didcot OX11 0QX, *United Kingdom
Water as the most abundant substance in all living organisms is essential for the functioning of proteins and a number of other biomolecules [1]. Despite numerous investigations on the relation of the water dynamics and the protein motion [2] the coupling of the solvent and the protein dynamics is still debated [3]. Here we report on quasielastic neutron scattering (QENS) measurements on myoglobin solvated in different mixtures of water and glycerol [4]. Varying the solvent composition and using selective deuteration allows us to emphasize different dynamical processes. We discuss mean square displacements revealing the onset of solvent and protein motions on the experimental time-scale and the nature of the dynamical processes derived from the measured dynamic structure factors.
[1] H. D. Middendorf, Physica B 226, 113 (1996).
[2] D. Vitkup et al., Nature struct. biol. 7, 34 (2000); M. Tarek et al., Phys. Rev. Lett. 88, 138101 (2002); P. W. Fenimore et al., P. Natl. Acad. Sci. 99, 16047 (2002).
[3] P. W. Fenimore et al., P. Natl. Acad. Sci. 101, 14408 (2004).
[4] F. Kargl, H. Jansson, F. Fernandez-Alonso, and J. Swenson (submitted)