Regensburg 2007 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 26: Poster Session II
BP 26.13: Poster
Donnerstag, 29. März 2007, 17:00–19:30, Poster B
Single molecule studies of eukaryotic transcription using optical tweezers — •Adam Muschielok1, Joanna Andrecka1, Florian Brückner2,1, Patrick Cramer2,1, and Jens Michaelis1 — 1Departement Chemie und Biochemie, Ludwig-Maximilians-Universität München, Deutschland — 2Gene Center Munich, Ludwig-Maximilians-Universität München, Deutschland
Our goal is to study the molecular mechanisms of the eukaryotic transcription process. Therefore we monitor the activity of single RNA Polymerase II (RNAP) molecules during RNA elongation using optical tweezers. We are interested in the elongation process and in the effects of transcription cofactors on RNAP activity.
We present preliminary data together with simulations to discuss the data analysis.