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DPG

Berlin 2008 – scientific programme

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BP: Fachverband Biologische Physik

BP 1: Cell Migration and Tissue Dynamics

BP 1.11: Talk

Monday, February 25, 2008, 12:45–13:00, C 243

Simulations and model validation by measurements in an isolated rabbit heart — •Steffen Bauer1, Inaki Romero1, Rodrigo Weber dos Santos2, Hans Koch1, and Markus Bär11PTB Berlin — 2Univ. Juiz de Fora, Brazil

Time-resolved surface activation time maps recorded from isolated rabbit hearts were analyzed in order to compare them with analogue maps generated by a computer model. Recordings were obtained under normal conditions as well as after the administration of ajmaline and palmitoleic acid (PA). In parallel, the measured quantities were simulated in a realistic computer model of the rabbit heart. The effect of ajmaline was reproduced by reducing the conductivity of sodium channels G_Na in the model. It was observed that addition of a given amount of ajmaline leads to an increase of the QRS time of up to 33 % and a decrease of typical velocities by 20-40 % with respect to normal conditions. A velocity decrease of about 20 % was reproduced in the computer model by a reduction of the G_Na by 60 %. Such a change in the model induces a corresponding increase of the QRS time by 20%. In contrast, administration of PA leaves the QRS time unchanged, while it reduces the speed by a similar margin as the ajmaline.

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