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BP: Fachverband Biologische Physik

BP 20: Regulation and Signaling

BP 20.5: Talk

Thursday, February 28, 2008, 11:00–11:15, C 243

Boolean Model of Fission Yeast Cell Cycle predicts mutations — •Maria Davidich and Stefan Bornholdt — Intitute for Theoretical Physics

A Boolean model [1] of the key regulators of the fission yeast cell cycle was built. The advantage of the model is that it is purely constructed on a wiring diagram of known biochemical reactions; no extra parameters enter the model. However, even though one needs much less information about the system, the model reproduces the right sequence of protein activity states during the cell cycle. This sequence appears to be robustly implemented in the regulatory network, its last state G1 corresponds to the biggest attractor of the system. Surprisingly, this simple model can also describe mutations of the regulatory proteins. We test the model starting from the different initial conditions corresponding to overexpression and underexpression of the proteins. The tests show that other attractors agree with mutations found in experiments.

[1] Davidich M.I., Bornholdt S. Boolean network predicts cell sequence of fission yeast. www.arhiv.org/abs/0704.2200 (Submitted to PLOS ONE)