Dresden 2009 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 17: Poster II

BP 17.43: Poster

Mittwoch, 25. März 2009, 17:15–19:45, P3

Stability analysis and maneuver of gene regulation networks — •Joseph Zhou and Thilo Gross — Max Planck Institute for the Physics of Complex Systems, Noethnitzer Strasse 38, Dresden

A gene regulation network can be viewed as a complex system with the ability to switch back and forth between different gene expression patterns due to a variety of intrinsic or extrinsic perturbation signals. More and more evidences show that malfunctioning cells, such as cancer cells, are not just the accumulation of random delirious gene mutations. Instead, it has an erroneous re-access of proliferating embryonic programs as local attractors which are embedded in the gene regulation network. Could we induce these cells out of these attractors by systematically over-expressing a well-designed combination of genes? For example, the current research of Induced pluripotent stem cell (iPS) is more an art of cell biologists than a well-founded science. The protocol of the combination of different genes, the ratio of these components, the timing and duration of over-expressing these genes is totally dependent on the try-and-error and past know-hows. It is badly needed to perform a systematic gene regulation network study to give some sound guidance for the cell reprogramming. In this research, we emply a general dynamic system model for a cell reprogramming from adult pancreatic exocrine cells to beta-cells to address questions above.