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BP: Fachverband Biologische Physik

BP 18: Regulation and Signaling

BP 18.12: Talk

Thursday, March 26, 2009, 13:00–13:15, HÜL 186

Drug absorption in a three-compartment model — •Niko Komin and Raúl Toral — IFISC (UIB-CSIC), Palma de Mallorca, Spain

For the understanding of pharmacological phenomena, a variety of compartment models were and are developed. The concept of interconnected pools, into which the drug is administered, searches solutions for the concentration evolution over time in the different compartments. The connections can be linear or non-linear, the system can be open or closed, concerning its interchange with the environment.

An analytic solution for any of the models would be of great value for understanding experimental data and refining the underlying assumptions. Here we want to present a mathematical way of transforming the system into a different picture and propose an adequate approximation to it. As this is a general approach we will explicitly do that on a closed three-compartment model with a Michaelis-Menten non-linearity, as a representation of a P-gp limited antibiotic absorption [1], and show how it can be extended to other models.

References:

1. Gonzalez-Alvarez et al (2005) Xenobiotica.