Dresden 2009 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 2: Biopolymers and Biomaterials (joint session BP/CPP)
BP 2.8: Vortrag
Montag, 23. März 2009, 12:45–13:00, ZEU 260
Mineralization kinetics and heterogeneity of mineral content in bone — •Carolin Lukas1, Harald Engel2, Peter Fratzl1, Paul Roschger3, Klaus Klaushofer3, and Richard Weinkamer1 — 1Max Planck Institute of Colloids and Interfaces, Department of Biomaterials, Potsdam, Germany — 2TU Berlin, Germany — 3Ludwig Boltzmann Institute of Osteology, Vienna, Austria
An important factor for the mechanical behaviour of bone at the material level is the amount and the distribution of mineral. The heterogeneous distribution of the bone mineral is due to the continuous remodelling of bone and the consecutive mineralization process. Bone mineralization increases the stiffness of each bone packet by increasing its mineral content. The mineralization kinetics is characterized by the mineralization law which describes the increase in the mineral content in a bone packet as a function of time. Remodelling and mineralization lead to a patchwork of bone elements with different mineral contents. Their frequency distribution, called the bone mineralization density distribution (BMDD), can be measured experimentally and modelled using a continuity equation [1, 2]. Extending the theoretical framework the influence of changes in the mineralization kinetics due to administration of drugs or disease on the BMDD can be described, which is of fundamental interest to medicine. We will present model predictions and compare them to experimental data.
[1] D. Ruffoni et al., Bone, 40(5), 2007.
[2] D. Ruffoni et al., JBMR 2(6), 2008.