Dresden 2009 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 22: Transport Processes and Cellular Trafficking
BP 22.4: Vortrag
Donnerstag, 26. März 2009, 15:15–15:30, ZEU 260
A dynamic model for the morphogenesis of the Golgi apparatus — •Jens Kuehnle1,2, Julian Shillcock2, Ole G. Mouritsen2, and Matthias Weiss1 — 1DKFZ, Heidelberg, Germany — 2Memphys-Center, University of Southern Denmark
While there has been considerable progress in understanding the molecular biology of the secretory pathway of mammalian cells, the fundamental question of how the most prominent and complex organelle of the pathway, the Golgi apparatus, is formed and maintained has remained largely elusive. Using a minimal self-organizing scheme based on incoming transport from the nearby endoplasmic reticulum and aging of Golgi fragments ('cisternal maturation'), we are able to explain the de novo formation of a Golgi apparatus. Moreover, we can determine a region of the models phase space for which secretion rates support the formation of a proper stack of Golgi cisternae. Our simulations are consistent with analytical considerations and agree well with existing experimental data.