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BP: Fachverband Biologische Physik

BP 7: Poster I

BP 7.32: Poster

Montag, 23. März 2009, 17:45–20:00, P3

The mechanisms of lipid membrane-induced IAPP fibrillogenesis and its inhibition — •Sebastian Tiemeyer¹, Florian Evers¹, Christoph G. Jeworrek², Michael Paulus¹, Bernd Struth³, Metin Tolan¹, and Roland Winter² — ¹Faculty of Physics / DELTA, TU Dortmund, 44221 Dortmund, Germany — ²Faculty of Chemistry, TU Dortmund, 44221 Dortmund, Germany — ³Deutsches Elektronen-Synchrotron, HASYLAB, Notkestr. 85, 22607 Hamburg, Germany

Protein misfolding plays an important role in many diseases like Alzheimer's, Parkinson's or type 2 diabetes mellitus. In the latter case, IAPP is thought to cause the death of insulin-producing beta-cells in the pancreatic islets of Langerhans. Previous experiments propose aggregation of IAPP to amyloid fibrils at beta-cell membranes followed by membrane disruption. X-ray reflectivity (XRR) experiments were performed at the beamline BW1 at HASYLAB in order to investigate the IAPP - lipid membrane interaction in the presence and absence of the red wine compound resveratrol. From the XRR data, we were able to identify the status of nucleation, aggregation and fibrillation of IAPP at the lipid membrane interface. Furthermore, the inhibition of the aggregation process by resveratrol was revealed.