Dresden 2009 – wissenschaftliches Programm

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 2: Focus: Amphiphilic Systems II

CPP 2.5: Hauptvortrag

Montag, 23. März 2009, 15:45–16:15, ZEU 222

Molecular Reorganization during Membrane Adhesion and Fusion — •Reinhard Lipowsky — Max Planck Institute of Colloids and Interfaces, Potsdam/Golm, Germany

The molecules within biomimetic and biological membranes are rather mobile and can reorganize themselves in various ways. During membrane adhesion, this reorganization leads to the formation of domain patterns induces by the topography of the underlying substrate [1] or by the clustering of adhesion molecules [2,3]. During membrane fusion, the molecules of the adjacent membranes are reorganized to form a fusion pore (or neck). One particularly simple way to induce fusion is provided via membrane tension. [4,5,6] One fusion pathway consists of interbilayer flips and nucleation of a hemifused membrane segment with two tension-dependent energy barriers. [5] Another pathway involves hemifusion via the rupture of one membrane. [6]

[1] B. Rozycki, T. Weikl, and R. Lipowsky, Phys. Rev. Lett. 100, 098103 (2008) [2] T. Weikl and R. Lipowsky, Biophys. J. 87, 3665 (2004) [3] M. Asfaw, B. Rozycki, R. Lipowsky, and T. Weikl, Europhys. Lett. 76, 703 (2006) [4] J. Shillcock and R. Lipowsky, Nature Materials 4, 225 (2005) [5] A. Grafmueller, J. Shillcock, and R. Lipowsky, Phys. Rev. Lett. 98, 218101 (2007) [6] L. Gao, R. Lipowsky, and J. Shillcock, Soft Matter 4, 1208 (2008)