München 2009 – wissenschaftliches Programm
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ST: Fachverband Strahlen- und Medizinphysik
ST 4: Biophysical effects of very slow and of fast ions
ST 4.2: Vortrag
Dienstag, 10. März 2009, 18:00–18:15, A021
Setup of a measuring station for the analysis of DNA-damage induced in cells by protons — •Philipp Schrögel1, Andreas Teufel1, Cecilia Pizzolotto1, Christian Vogel1, Wolfgang Eyrich1, and Luitpold Distel2 — 1Universität Erlangen-Nürnberg, ECAP — 2Universitätsklinikum Erlangen, Strahlenklinik
The understanding of microbiological effects of densely ionising hadron beams, especially the repair-mechanisms of clustered DNA-damage (bulky lesions), has basic relevance for the conception of future therapy facilities. The vertical beam at the Erlangen Tandem-Van-De-Graaff accelerator allows radiobiological experiments with protons with a maximum energy of 11 MeV. The measuring station has been optimised and extended. A new data acquisition system on basis of the VMEbus has been developed for the readout of the beamprofile- and monitor detector. The class-based modular programming of the readout software and the integration in the data analysis framework ROOT allow a flexible and extendable use. For determining the energy-loss properties of the protons, the energy spectra have been measured with the beam going through different absorberfoils and have been compared with simulation data. First test measurements with the pixelated silicon detector Medipix showed promising data for the energy and spatial distribution of the protons. With the irradiation of primary human fibroblasts in a small angle to the beam, the DNA damage along the tracks of single protons through the nucleus could be visualised. This allows further investigations of the repair-mechanisms.