Dresden 2011 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 1: Statistical Physics in Biological Systems I (joint DY, BP)
BP 1.9: Vortrag
Montag, 14. März 2011, 12:45–13:00, ZEU 250
Spontaneous spiking in presence of an autaptic feedback loop — Yunyun Li1, •Gerhard Schmid1, Peter Hänggi1, and Lutz Schimansky-Geier2 — 1Universität Augsburg, Germany — 2Humboldt Universität zu Berlin, Germany
The effect of intrinsic channel noise on the dynamics of a neuronal cell with a delayed feedback loop is investigated [1]. The loop is based on the so-called autapse phenomenon in which dendrites establish not only connections to neighboring cells but as well to its own axon. The modeling is achieved in terms of a stochastic Hodgkin-Huxley model containing such a built in delayed feedback. The fluctuations stem from intrinsic channel noise, being caused by the stochastic nature of the gating dynamics of ion channels. The delayed feedback manifests itself in the occurrence of bursting and a rich multimodal interspike interval distribution, exhibiting a delay-induced reduction of the spontaneous spiking activity at characteristic frequencies. Moreover, a specific frequency-locking mechanism is detected for the mean interspike interval.
[1] Y. Li, G. Schmid, P. Hänggi, L. Schimansky-Geier, Phys. Rev. E, in press (arXiv:1009.5198)