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BP: Fachverband Biologische Physik

BP 11: Posters: Single-Molecule Biophysics

BP 11.10: Poster

Monday, March 14, 2011, 17:15–20:00, P3

Stochastic enzymatic reactions with spatially arranged enzymes — •Fabienna Arends, Alexander Buchner, and Ulrich Gerland — Arnold Sommerfeld Center for Theoretical Physics (ASC) and Center for NanoScience (CeNS), Department of Physics, Ludwig-Maximilians-Universität München

To efficiently catalyze multi-step biochemical reaction pathways, cells have optimized the synergistic action of a multitude of enzymes. Not only do they carefully control the concentrations and activities of enzymes as a function of the external conditions, but in many known cases cells also coordinate the enzymes that catalyze different steps in the same biochemical reaction pathway by arranging them in self-assembled multi-enzyme complexes. In these complexes, single enzymes of several types are localized on well-defined spots. So far, the theoretical study of these systems has focused on the deterministic level. Here, we investigate the behaviour of spatially arranged enzymes in different configurations including stochastic effects.