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BP: Fachverband Biologische Physik

BP 12: Posters: New Technologies

BP 12.2: Poster

Monday, March 14, 2011, 17:15–20:00, P3

Biocompatibility of single crystalline Fe₇₀Pd₃₀ ferromagnetic shape memory films for cell actuation — •Mareike Zink¹, Yanhong Ma², and S. G. Mayr² — ¹Abteilung Physik der weichen Materie, Fakultät für Physik und Geowissenschaften, Universität Leipzig, Leipzig, Germany — ²Leibniz-Institut für Oberflächenmodifizierung e.V., Translationszentrum für Regenerative Medizin, Fakultät für Physik und Geowissenschaften, Universität Leipzig, Germany

Ferromagnetic shape memory alloys (FSMAs) have received great attention as an exciting class of smart functional materials. They exhibit large reversible strains at moderate stresses with external controllability at constant temperatures which make them excellent candidates for biomedical actuation devices. FSMAs bear the significant potential for miniaturized devices for single cell actuation which is capable of yielding magnetically controllable shear strains and/or volume dilations. However, the biocompatibility of this material must first be well confirmed as it has not been done yet. Thus, our work focuses on the interaction of fibroblast cells with single crystalline Fe₇₀Pd₃₀ FSMA films on MgO substrates. Additionally, corrosion resistance of the films was obtained employing simulated body fluid (SBF) tests. Calcium-phosphate aggregates with granular microstructure were detected on the film surface after soaking in SBF. Cell viability and biocompatibility tests with NIH 3T3 cells revealed that the cells adhered and proliferated on the FSMA surface, whereas cells were smaller compared to cells on culture dish surfaces. Biocompatible polymer coatings on the Fe₇₀Pd₃₀ film can be employed to improve cell-substrate interactions.