Dresden 2011 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 13: Posters: Biological Membranes
BP 13.9: Poster
Montag, 14. März 2011, 17:15–20:00, P3
Self Organized Criticality and Fractal characteristics in Ion Channels: studies on Voltage Dependent Anion Channel — •Subhendu Ghosh1, Jyotirmoy Banerjee2, Smarajit Manna2, Mahendra K. Verma3, Naveen K. Bhatraju4, and Mrinal K. Das2 — 1Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany — 2Department of Biophysics University of Delhi South Campus New Delhi 110021, India. — 3Indian Institute of Technology, Kanpur Kanpur 208016, India. — 4School of Life Sciences University of Hyderabad Hyderabad, 500046, India
Self Organized Criticality (SOC) is a phenomenon which is highly talked about in various fields. We discuss the existence of SOC in the electrical behavior of the artificial and cell membranes, specifically in ion channels. We have measured the single-channel and multi-channel currents (with noise) through Voltage Dependent Anion Channel (VDAC) isolated from rat brain mitochondria, reconstituted into Bilayer Lipid Membrane (BLM) under various applied voltages. Power Spectrum analysis of Open Channel current time series data indicates power-law noise of 1/f nature. We argue that the origin of 1/f noise in open ion channels is self-organized-criticality as evident from waiting time statistics of big events. In addition we demonstrate that the experimental time series data of gating of VDAC at selected membrane potentials have Fractal behavior. On the other hand, we demonstrate that the multi-channel VDAC current (open) shows Multi-fractal properties. We conclude that Self-Organized-Criticality and Fractals are the realities of Ion Channels.