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BP: Fachverband Biologische Physik

BP 4: DNA \& DNA Enzymes

BP 4.1: Invited Talk

Monday, March 14, 2011, 14:00–14:30, ZEU 260

Single-molecule detection of DNA repair in real-time — •Terence Strick¹, Kevin Howan¹, Nigel Savery², Seth Darst³, and MM2M FP7 Consortium⁴ — ¹CNRS Institut Jacques Monod Paris, France — ²University of Bristol, UK — ³Rockefeller Institute, NY, USA — ⁴Erasmus Univ., Rotterdam

We describe the bottom-up reconstruction of DNA repair pathways using single-molecule nanomanipulation methods. This allows us to observe in real-time the initial steps of DNA repair and build up kinetic models for repair processes. We discuss a variety of DNA repair systems and show in which ways these systems are mechanosensitive or not.