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BP: Fachverband Biologische Physik

BP 4: DNA \& DNA Enzymes

BP 4.4: Vortrag

Montag, 14. März 2011, 15:00–15:15, ZEU 260

A Stochastic Model of DNA Replication Dynamics — •Daniel Löb and Barbara Drossel — Institut für Festkörperphysik, TU Darmstadt

Inspired by detailed cell-biological data on the dynamics of DNA replication during S phase, we present a stochastic model of DNA replication dynamics that allows for a quantitative comparison between model parameters and data.

An important ingredient of the model is the structuring of DNA into zones of euchromatin and heterochromatin, which have different rates of replication initiation. The sizes of these zones affect the time course of replication of the two chromatin types.

Further important model features are the induced initiation of replication in the vicinity of replication forks and a limitation of the number of replication forks due to the limited availability of essential replication proteins.