Dresden 2011 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 35: Poster: Micro- and Nanofluidics
CPP 35.16: Poster
Mittwoch, 16. März 2011, 17:00–19:00, P2
Continuous chiral separation in a post array — •Lukas Bogunovic1, Marc Fliedner2, Sonja Wegener1, Peter Reimann2, Dario Anselmetti1, and Jan Regtmeier1 — 1Experimental Biophysics & Applied Nanoscience, Faculty of Physics, Bielefeld University, Germany — 2Condensed Matter Theory, Faculty of Physics, Bielefeld University, Germany
About one half of the drugs on the market are chiral and only 25 \% of all drugs are administered as pure enantiomers [1]. Because the human metabolism (as for all living organisms) functions in a highly chiral manner, it interacts differently with the two enantiomers. Consequently, the two forms have mostly different pharmacological activities underlining the need for preparational and analytical techniques. Traditionally, chiral selectors are used that specifically bind only one form. This approach, however, requires to identify a new selector for every new drug.
Here, we present the first enantioselective selector-free separation in a microfluidic post array using micrometer sized model particles. The post array is tilted with respect to the main channel axis breaking the symmetry. The sample is continuously introduced and the two enantiomers are deflected into different directions so that they could be collected in distinct reseroirs.
For future application, we would like to extend our device from quasi-2D to 3D and further miniaturize it to address drugs.
[1] G Gübtiz and MG Schmid Biopharamceutics & Drug Disposition 22 (2001) 291-336