Dresden 2011 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 38: Poster: Colloids and Complex Liquids
CPP 38.3: Poster
Mittwoch, 16. März 2011, 17:00–19:00, P2
Pressure Dependence of the Interaction Potential of Protein Solutions — •Martin Schroer1, Jonas Markgraf2, Florian Wieland1, Christoph Sahle1, Johannes Möller1, Michael Paulus1, Metin Tolan1, and Roland Winter2 — 1Fakultät Physik / DELTA, TU Dortmund, Maria-Goeppert-Mayer-Str. 2, 44227 Dortmund (Germany) — 2Fakultät Chemie, Physikalische Chemie I, TU Dortmund, Otto-Hahn Str. 6, 44227 Dortmund (Germany)
Pressure, one of the fundamental thermodynamic variables, allows to change in a controlled and reversible way the intermolecular interactions of proteins in solution without the major perturbations produced by changes in temperature or chemical composition. Moreover, hydrostatic pressures are also relevant for understanding life under extreme conditions, as for instance in exobiological or deep sea environments (where organisms have to cope with pressures up to ~1 kbar). Hence, studying protein-protein interaction as a function of pressure will give a deeper insight into the high stability of dense protein solutions (as they occur intracellularly) in biosystems living under hydrostatic pressure conditions. We present recent results of the influence of pressure on the structure and protein-protein interaction potential of dense protein solutions studied using small angle X-ray scattering (SAXS).