Dresden 2011 – scientific programme
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ST: Fachverband Strahlen- und Medizinphysik
ST 1: Radiation Therapy I Fast Ions: Production, Physical Dosimetry, Biological Effets, Medical Effects
ST 1.7: Talk
Monday, March 14, 2011, 16:00–16:15, POT 112
Effects of X-ray and heavy ion radiation on organotypic slice cultures of liver and pancreas — •Mareike Müller1,2,3, Marco Durante2,3,4, Gisela Taucher-Scholz2, Francesco Natale3, Horst Stöcker2,3, and Horst-Werner Korf1 — 1Dr. Senckenbergisches Chronomedizinisches Institut, Fachbereich Medizin, Goethe-Universität Frankfurt/Main — 2GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt — 3Frankfurt Institute for Advanced Studies, Frankfurt/Main — 4Institut für Festkörperphysik, Technische Universität Darmstadt, Darmstadt
Cancers developing from liver and pancreas still have a poor prognosis and the efficacy of current therapeutic strategies is very limited. Properly timed X-ray and heavy ion irradiation may strongly improve the treatment of these cancers, but little is known how normal and neoplastic tissues from liver and pancreas respond to these treatments at various daytimes. Our interdisciplinary project aims at answering these questions by investigating the effects of X-ray and heavy ion irradiation on organotypic slice cultures (OSC) of liver and pancreas. Investigations of OSC present a novel approach in radiation research, they provide more relevant results than analyses of pure cell lines because OSC maintain the three-dimensional parenchymal architecture and the stromal compartment with functional extracellular matrix, the latter being an essential determinant of the tissue response to irradiation.
We present first results from X-ray irradiated OSC, analyzed for DNA damage and the number of proliferating and apoptotic cells.