Berlin 2012 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 10: Biopolymers and Biomaterials (with CPP)

BP 10.9: Vortrag

Dienstag, 27. März 2012, 12:00–12:15, H 1058

Superparamagnetic Iron Oxide Nanoparticles as Radiosensitizer for Radiation Therapy — •Anja Sommer¹, Stefanie Klein¹, Luitpold Distel², and Carola Kryschi¹ — ¹Department of Chemistry and Pharmacy, Institute of Physical Chemistry I, University of Erlangen, Egerlandstr. 3, 91058 Erlangen, Germany — ²Department of Radiation Oncology, University of Erlangen, Universitaetsstr. 27, 91058 Erlangen, Germany

Superparamagnetic iron oxide nanoparticles (SPION) have been widely used experimentally for numerous in vivo applications such as magnetic resonance imaging (MRI) contrast enhancement, hyperthermia and targeted drug delivery. we present the synthesis of surface-stabilized ultrasmall superparamagnetic iron oxide nanoparticles. In this contribution, we will report on functionalized SPION with sizes between 4 and 15 nm which were synthesized by alkine coprecipitation or thermal decomposition and subsequently coated with biocompatible acids. The differently stabilized SPION were fully characterized using HRTEM, XRD, SQUID, FTIR and Raman spectroscopy, XPS, TGA-MS and TGA-IR coupling and zeta potential measurements. Furthermore we present studies about their biocompatibility for cancer cell lines and their potential as radiosensitizer in radiation therapy.