Berlin 2012 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 17: Posters: Physics of Cells
BP 17.38: Poster
Mittwoch, 28. März 2012, 17:30–19:30, Poster A
Mechanics and morphology of the interface between two cell populations during tissue growth — •maryam aliee1, Jens-Christian Röper2, Christian Dahmann2, and Frank Jülicher1 — 1Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany — 2Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
During the development of tissues distinct cellular compartments are established. The interface between these compartments remains sharply defined and on average straight during growth and development. Using a vertex model to describe cell mechanics we discuss several physical mechanisms that contributes to interface morphology. We analyze the influence of cell bond tension, cell proliferation, oriented cell division, cell area pressure, and cell elongation, on the time dependence of interface morphology and mechanics. We show that a local increase in cell bond tension at the interface and a reduced cell proliferation rate in the vicinity of the interface produce effective interfacial tension and reduce the roughness of interfaces significantly. We also study the case in which orientation of cell division depends on cell shape and the case in which cell division rate is affected by cell area pressure. These two mechanisms have negligible contribution to the interfacial tension, however the interface roughness is significantly reduced when combined with a local increase of cell bond tension at the interface. In the case where cells are elongated by external shear stress, the interfacial tension is changed slightly, while there is a strong effect straightening the interface.