Berlin 2012 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 18: Posters: Statistical Physics in Biological Systems

BP 18.35: Poster

Mittwoch, 28. März 2012, 17:30–19:30, Poster A

Modeling of the theta rhythm patterns in septo-hippocampal area — •Sebastian Milster, Anastasia Lavrova, and Lutz Schimansky-Geier — HU Berlin, Institut für Physik

Theta (3 - 12 Hz) and gamma (30 - 70 Hz) oscillations in rodent`s hippocampal and septal areas have been throuroughly studied in vivo as well as in vitro. They occur during distinct cognitive states. It has been shown that theta and gamma oscillations in hippocampus are modulated by inhibitory inputs from the septum.

The focus of this work is to study the influence of the connection between the septum and the hippocampus CA3 area. We use the Hodgkin-Huxley equations to construct a minimal septo-hippocampal circuit. By changing the coupling strengths between the cells we define the parameter range at which different oscillatory regimes emerge. We analyze how the main characteristics of self-sustained oscillations as phase shift and frequency change at the switching between different rhythms. The model is to examine the mechanism of disinhibition and its contribution to the modulation of these rhythms.