Berlin 2012 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 26: Posters: Membranes and Vesicles

BP 26.17: Poster

Donnerstag, 29. März 2012, 17:30–19:30, Poster A

elastic model for endocytosis of clathrin plaques — •yu-hsein lin¹, david jasnow², and hsuan-yi chen³ — ¹Graduate Institute of Biophysics, National Central University, Taiwan R.O.C — ²Department of Physics,University of Pittsburgh, Pittsburgh, USA — ³Department of Physics, National Central University, Taiwan R.O.C

There are two distinct structures of the clathrin- coated vesicles in the early process of the clathrin-mediated endocytosis, one is spherical pits and the other one is flat plaques. Both of them finally form vesicles and enter the cell.

From the observation of experiments, plaques are only found on the cell membrane which is adherent to the substrates, but pit can be found everywhere on the cell membrane. Experiments show that the actin polymerization is essential for both the formation and the invagination of a plaque. But the details of the process, how a coated membrane is lifted on the cell membrane, remain unknown.

In order to understand the mechanism of the invagination of a plaque, we built a model in which the release of the elastic free energy of the growing actin network lead to the detachment of the membrane domain with clathrin plaque from the substrate. Our study suggests a new role played by the actin network on the subcellular process.