Berlin 2012 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 29: Posters: Regulation
BP 29.8: Poster
Donnerstag, 29. März 2012, 17:30–19:30, Poster A
Effects of receptor location and transport mechanism on bacterial quorum sensing — •Bastian Drees1,2 and Ilka B. Bischofs1,2 — 1Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany — 2BioQuant, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany
In a process known as quorum sensing (QS) bacteria produce, secrete and sense autoinducer molecules (AI) to communicate and get information about their environment, such as cell density and the extent of AI loss by diffusion or flow. QS systems found in different bacteria differ in the way the AIs are secreted and in the way they are sensed. We theoretically investigate the sensitivity and robustness of different QS architectures and the environmental conditions under which these architectures show optimal sensing behavior. We find that active export barely has any effect on external sensing, while any kind of active transport (import or export) increases the noise in internal sensing systems. Furthermore, our model suggests that systems with extracellular sensors are preferred at low AI concentrations, while internal sensing might be preferred at intermediate AI concentrations; a result supported by experimental data.