Berlin 2012 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 8: Posters: Biopolymers and Biomaterials (with CPP)
BP 8.4: Poster
Montag, 26. März 2012, 17:30–19:30, Poster A
Ab-initio characterization of potential siderophore-mediated metal transport systems — •Angelica Zacarias1, Mabel Moreno1,2, Mato Knez1, Luis Velasquez2, Andrea Porzel3, and E.K.U. Gross1 — 1Max Planck Institute of Microstructure Physics, Weinberg 2, 06120 Halle (Saale) — 2CEDENNA and Universidad de Santiago de Chile, Avda. Ecuador 3493, Estación Central, Santiago, Chile — 3Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle (Saale)
The high affinity of enterobactin for iron has a wide range of biological applications (such as the treatment of bacterial diseases) as it allows its use for complex-mediated iron transport.
We present preliminary results that analyze the electronic and spectroscopic properties of the bare enterobactin as well as other metal-enterobactin systems.
We will show that the computer aided characterization of the products synthesized via Atomic Layer Deposition (ALD) techniques allows a better understanding not only of the iron-enterobactin association but also the further affinity of the enterobactin and iron-enterobactin for other metals. The extensive knowledge of this relationship and the use of ALD as synthetic technique has potential uses of the enterobactin complex in the treatment of bacterial diseases as well as in the area of environmental contamination.