Berlin 2012 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 9: Focus: Systems Biology of Bacteria (with jDPG)
BP 9.7: Vortrag
Dienstag, 27. März 2012, 12:00–12:15, E 020
Unified description of Min protein patterns in vivo and in vitro — •Mike Bonny1, Elisabeth Fischer-Friedrich2, Martin Loose4, Petra Schwille3, and Karsten Kruse1 — 1Theoretische Physik, Universität des Saarlandes, Postfach 151150, 66041 Saarbrücken, Germany — 2Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Straße 38, 01187 Dresden, Germany — 3Biophysics, BIOTEC, TU Dresden, Tatzberg 47/49, 01307 Dresden, Germany — 4Harvard Medical School, Department of Systems Biology, 200 Longwood Avenue, Warren Alpert Building, Boston, MA 0211
The bacterial proteins MinD and MinE self-organize into a variety of fascinating patterns in the presence of a membrane. In vivo, standing and traveling waves as well as bistable stationary states are observed. In vitro they form plane and spiral waves. Several models explain Min protein pattern formation by cooperative attachment of MinD to the membrane and MinE-induced detachment from the membrane. However, a description reproducing all observed patterns is missing. We have found that MinE can bind by itself transiently to the membrane [1,2]. Analyzing mean field and stochastic models of Min protein dynamics, we find that our description shows all observed in vivo and in vitro patterns if we include the transient membrane interaction of MinE.
[1] M. Loose et al., Struct. Mol. Biol., 18, 577 (2011).
[2] K. Park et al., Cell, 146, 396 (2011).